Simple activation by acid of latent Ru-NHC-based metathesis initiators bearing 8-quinolinolate co-ligands

• Julia Wappel,
• Roland C. Fischer,
• Luigi Cavallo,
• Christian Slugovc and
• Albert Poater

Beilstein J. Org. Chem. 2016, 12, 154–165, doi:10.3762/bjoc.12.17

• towards the control of polymer functionalization and living or switchable polymerizations. Keywords: acid; activation by acid; metathesis; polymer; quinolin; ruthenium; triggerable; Introduction The modulation of the activity of enzymes by chemical triggers, e.g., by allosteric binding is ubiquitous in

• transforming growth factor-beta (TGF-beta) are associated with a broad variety of diseases and that TGF-beta is biologically inert when takes part of the complex that bears its corresponding peptide [34]. From this latter latent complex, most available immunoassays require controlled activation by acid to

• release the TGF-beta. On the other hand, myostatin belongs to the transforming growth factor 13 superfamily, known because it decreases the skeletal muscle mass. Bearing the fact that experiments have shown that myostatin activity is detected only after activation by acid [35], myostatin demonstrates to